medinfoАктуальные проблемы теоретической и клинической медициныActual Problems of Theoretical and Clinical Medicine2790-12892790-1297Казахстанско-Российский медицинский университет10.64854/2790-1289-2026-51-1-09medinfo-1021Research ArticleОБЗОР ЛИТЕРАТУРЫREVEWSПУТИ ПОВЫШЕНИЯ ЭФФЕКТИВНОСТИ И БЕЗОПАСНОСТИ НЕСТЕРОИДНЫХ ПРОТИВОВОСПАЛИТЕЛЬНЫХ СРЕДСТВ: РОЛЬ ГЛИЦИРРИЗИНОВОЙ КИСЛОТЫWAYS TO IMPROVE THE EFFICACY AND SAFETY OF NONSTEROIDAL ANTI-INFLAMMATORY DRUGS: THE ROLE OF GLYCYRRHIZIC ACIDhttps://orcid.org/0009-0004-5457-973XАзенЖ. Ш.AzenZh. Sh.

Магистрант 2 курса, кафедра фармацевтических дисциплин. 

azenzh2@gmail.comhttps://orcid.org/0009-0006-6047-8577ЖорабекТ. Б.ZhorabekT. B.

Магистрант 2 курса, кафедра фармацевтических дисциплин. 

abenkenzegul@gmail.comhttps://orcid.org/0009-0005-8697-6438АрыстановаТ. А.ArystanovaT. A.

д. фарм. наук, профессор, Лауреат Государственный премии РК

tanagul53@gmail.comНАО "Медицинский Университет Астана"КазахстанJSC «Astana Medical University»Kazakhstan20260104202601138155Copyright © Азен Ж.Ш., Жорабек Т.Б., Арыстанова Т.А., 20262026Азен Ж.Ш., Жорабек Т.Б., Арыстанова Т.А.Azen Z.S., Zhorabek T.B., Arystanova T.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://kazrosmedjournal.krmu.edu.kz/jour/article/view/1021Актуальность

Актуальность. В статье представлен аналитический обзор современных подходов к повышению эффективности и безопасности нестероидных противовоспалительных средств, широко применяемых в клинической практике при воспалительных и болевых синдромах. Несмотря на высокую терапевтическую эффективность, применение нестероидных противовоспалительных средств ассоциировано с развитием нежелательных лекарственных реакций, в том числе гастро- и гепатотоксичности, что существенно ограничивает их длительное использование. В этой связи особое внимание уделено роли глицирризиновой кислоты как природного противовоспалительного и цитопротекторного агента, обладающего антиоксидантными и мембраностабилизирующими свойствами. Приведены экспериментальные данные, подтверждающие потенциал комбинации нестероидных противовоспалительных средств с глицирризиновой кислотой для снижения токсичности и усиления противовоспалительного эффекта.

Цель исследования – систематизировать   данные литературы о современных подходах к снижению побочных эффектов нестероидных противовоспалительных средств и оценить возможность применения природного адаптогена, глицирризиновую кислоту для повышения   безопасности терапии.

Материалы и методы

Материалы и методы. Анализ данных литературы проведен на основе публикаций, проиндексированных в базах данных PubMed Central, Scopus, Web of Science, Google Scholar, а также опубликованных в научной электронной библиотеке за период 2000-2025 гг. Анализ более ранних публикаций обусловлен тем, что наиболее значимые исследования, посвященные комбинированию глицирризиновой кислоты с синтетическими препаратами, были до 2010 года. Критериями включения были экспериментальные и клинические исследования, а также обзорные статьи, посвященные фармакологическим свойствам нестероидных противовоспалительных средств, механизмам их побочного действия, а также биологической активности глицирризиновой кислоты и перспективам их совместного применения.

Результаты

Результаты. Анализ данных литературы показал, что повышения безопасности нестероидных противовоспалительных средств является актуальной проблемой современной фармакотерапии. Представленные в литературе исследования показывают, что глицирризиновая кислота – природный субстрат, обладающий выраженными противовоспалительными, антиоксидантными и цитопротекторными свойствами, – является потенциальным средством фармакологической коррекции нежелательных эффектов нестероидных противовоспалительных средств.

Выводы

Выводы. Комбинирование нестероидных противовоспалительных средств с глицирризиновой кислотой является перспективным направлением разработки более безопасных и эффективных лекарственных препаратов для противовоспалительной терапии.

Relevance

Relevance. This article presents an analytical review of current approaches aimed at improving the efficacy and safety of nonsteroidal anti-inflammatory drugs, which are widely used in clinical practice for inflammatory and pain syndromes. Despite their high therapeutic efficacy, nonsteroidal anti-inflammatory drugs are associated with adverse drug reactions, including gastro- and hepatotoxicity, which significantly limit their long-term use. In this context, particular attention is paid to glycyrrhizic acid as a natural anti-inflammatory and cytoprotective agent with antioxidant and membrane-stabilizing properties. Experimental evidence demonstrating the potential of combining nonsteroidal anti-inflammatory drugs with glycyrrhizic acid to reduce toxicity and enhance anti-inflammatory effects is presented.

Objective

Objective. To systematize current literature data on modern approaches to reducing adverse effects of nonsteroidal anti-inflammatory drugs and to evaluate the potential of glycyrrhizic acid as a natural adaptogen for improving therapy safety.

Materials and Methods

Materials and Methods. A literature analysis was conducted based on publications indexed in PubMed Central, Scopus, Web of Science, Google Scholar, as well as national scientific electronic libraries, covering the period from 2000 to 2025. Earlier studies were also included due to the relevance of key research on combinations of glycyrrhizic acid with synthetic drugs conducted prior to 2010. Inclusion criteria comprised experimental and clinical studies, as well as review articles addressing the pharmacological properties of nonsteroidal anti-inflammatory drugs, mechanisms of their adverse effects, and the biological activity of glycyrrhizic acid and its potential for combined use.

Results

Results. The analysis of the literature demonstrated that improving the safety profile of NSAIDs remains an important issue in modern pharmacotherapy. Glycyrrhizic acid, as a natural compound with pronounced anti-inflammatory, antioxidant, and cytoprotective properties, is considered a promising agent for the pharmacological correction of nonsteroidal anti-inflammatory drug-induced adverse effects.

Conclusions

Conclusions. The combination of nonsteroidal anti-inflammatory drugs with glycyrrhizic acid represents a promising approach for developing safer and more effective anti-inflammatory therapies.

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The authors declare that there are no conflicts of interest present.