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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medinfo</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальные проблемы теоретической и клинической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Actual Problems of Theoretical and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2790-1289</issn><issn pub-type="epub">2790-1297</issn><publisher><publisher-name>Казахстанско-Российский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medinfo-129</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>ИСПОЛЬЗОВАНИЕ ИФА ДЛЯ ОЦЕНКИ НАПРЯЖЕННОСТИ ИММУННОГО ОТВЕТА У ПАЦИЕНТОВ ИММУНИЗИРОВАННЫХ SARS-COV-2</article-title><trans-title-group xml:lang="en"><trans-title>THE USE OF ELISA TO ASSESS THE INTENSITY OF THE IMMUNE RESPONSE IN PATIENTS IMMUNIZED WITH SARS-CoV-2</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давлятшин</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Davlyatshin</surname><given-names>T. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давлятшина</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Davlyatshina</surname><given-names>Y. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Орынбаев</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Orynbaev</surname><given-names>M. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хайруллин</surname><given-names>Б. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Khairullina</surname><given-names>B. M.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5318-0995</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маншарипова</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Mansharipova</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Professor</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Решетников</surname><given-names>С. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Reshetnikova</surname><given-names>S. S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сизов</surname><given-names>А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sizov</surname><given-names>A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рахматуллин</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Rakhmatullina</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Садыков</surname><given-names>К. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Sadykov</surname><given-names>K. B.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-5"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Давлятшин</surname><given-names>Т. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Davlyatshin</surname><given-names>T. T.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маншарипов</surname><given-names>Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Mansharipov</surname><given-names>D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>студент</p></bio><bio xml:lang="en"><p>student</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">ТОО «Т-Хелпер»<country>Казахстан</country></aff><aff xml:lang="en">«T-Helper» LLP<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru">ГУ «Научно-исследовательский институт проблем биологической безопасности»<country>Казахстан</country></aff><aff xml:lang="en">PA «Scientific Research Institute of Biological Safety Problems »<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru">НУО «Казахстанско-Российский медицинский университет»<country>Казахстан</country></aff><aff xml:lang="en">NEI «Kazakh-Russian Medical University»<country>Kazakhstan</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru">АО «ВЕКТОР-БЕСТ»<country>Россия</country></aff><aff xml:lang="en">JSC «VECTOR-BEST»<country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-5"><aff xml:lang="ru">«Военный клинический госпиталь» МО РК<country>Казахстан</country></aff><aff xml:lang="en">«Military Clinical Hospital» MD RK<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>50</fpage><lpage>53</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Давлятшин Т.И., Давлятшина Е.В., Орынбаев М.Б., Хайруллин Б.М., Маншарипова А.Т., Решетников С.С., Сизов А., Рахматуллин А.В., Садыков К.Б., Давлятшин Т.Т., Маншарипов Д., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Давлятшин Т.И., Давлятшина Е.В., Орынбаев М.Б., Хайруллин Б.М., Маншарипова А.Т., Решетников С.С., Сизов А., Рахматуллин А.В., Садыков К.Б., Давлятшин Т.Т., Маншарипов Д.</copyright-holder><copyright-holder xml:lang="en">Davlyatshin T.I., Davlyatshina Y.V., Orynbaev M.B., Khairullina B.M., Mansharipova A.T., Reshetnikova S.S., Sizov A., Rakhmatullina A.V., Sadykov K.B., Davlyatshin T.T., Mansharipov D.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://kazrosmedjournal.krmu.edu.kz/jour/article/view/129">https://kazrosmedjournal.krmu.edu.kz/jour/article/view/129</self-uri><abstract><p>В ходе обследования на АТ к белкам зоны «шипов» и нуклеокапсида в группе самообратившихся пациентов, выявлена зависимость формирования стойкого иммунного ответа и тяжести течения заболевания от способности и скорости наработки АТ у инфицированных SARS-CoV-2 к белкам обеих зон вируса</p></abstract><trans-abstract xml:lang="en"><p>During the examination for antibodies to proteins of the «thorns» and nucleocapsid zone in a group of self-reversing patients, the dependence of the formation of a stable immune response and the severity of the disease on the ability and rate of production of antibodies in those infected with SARS-Co V-2 to proteins of both virus zones was revealed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>иммунный ответ</kwd><kwd>напряженность</kwd><kwd>SARS-CoV-2</kwd><kwd>иммуноглобулины</kwd><kwd>Nс-белок</kwd><kwd>S-белок</kwd></kwd-group><kwd-group xml:lang="en"><kwd>immune response</kwd><kwd>tension</kwd><kwd>SARS-CoV-2</kwd><kwd>immunoglobulins</kwd><kwd>Nc-prote in</kwd><kwd>S-protein</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">https://medikom.ua/ru/koronavirus-simptomy-iprofilaktika/#</mixed-citation><mixed-citation xml:lang="en">https://medikom.ua/ru/koronavirus-simptomy-iprofilaktika/#</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation 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