References

medinfo

Актуальные проблемы теоретической и клинической медицины

Actual Problems of Theoretical and Clinical Medicine

2790-12892790-1297

Казахстанско-Российский медицинский университет

10.24412/2790-1289-2022-1-1022

medinfo-13

Research Article

ОБЗОР ЛИТЕРАТУРЫ

REVEWS

АЛЛЕРГИЯ И РАК

ALLERGY AND CANCER

https://orcid.org/0000-0002-1560-2245

Кузьмин

Ю. А.

Kuzmin

Yu. A.

д.м.н., профессор

MD, Professor

yrkuz@mail.ru

НУО «Казахстанско-Российский медицинский университет»КазахстанNEI «Kazakh-Russian medical university»Kazakhstan

2022

11102022

011022

2022

Кузьмин Ю.А.

Kuzmin Y.A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://kazrosmedjournal.krmu.edu.kz/jour/article/view/13

Многие исследователи указывают на значительное снижение риска онкологической патологии у лиц, страдающих аллергическими заболеваниями. В настоящее время возросло понимание ключевой роли микроокружения в развитии опухоли. К ним относятся опухоль-ассоциированные макрофаги (TAM – tumor-associated macrophages), регуляторные Т-лимфоциты (Трег-клетки) и клетки - супрессоры миелоидного происхождения (MC). Известно, что IgE появляются при аллергии и эти антитела способны переформатировать проопухолевые макрофаги и Трег-клетки в сторону провоспалительного состояния и настраивать их на противоопухолевую функцию

Many researchers point to a significant reduction in the risk of oncological pathology in people suffering from allergic diseases. There is now an increased understanding of the key role of the microenvironment in tumor development. These include tumor-associated macrophages (TAMs), regulatory T-lymphocytes (Treg cells), and myeloid-derived suppressor cells (MCs). It is known that IgE appears in allergy and these antibodies are able to reformat protumor macrophages and Treg cells towards a proinflammatory state and tune them to an antitumor function.

ракаллергиямикроокружениеантитела IgE

cancerallergymicroenvironmentIgE antibodies

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The authors declare that there are no conflicts of interest present.