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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medinfo</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальные проблемы теоретической и клинической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Actual Problems of Theoretical and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2790-1289</issn><issn pub-type="epub">2790-1297</issn><publisher><publisher-name>Казахстанско-Российский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">medinfo-130</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>НЕОБХОДИМА ЛИ ТЕХНОЛОГИЯ С ИСПОЛЬЗОВАНИЕМ ПЛАЗМЫ, ОБОГАЩЕННОЙ ТРОМБОЦИТАМИ И ЛЕЙКОЦИТАМИ</article-title><trans-title-group xml:lang="en"><trans-title>IS THE TECHNOLOGY USING PLASMA ENRICHED WITH PLATELETS AND WHITE BLOOD CELLS NECESSARY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фазылов</surname><given-names>Т. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Fazylov</surname><given-names>T. R.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дуйсенов</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Duisenov</surname><given-names>N. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н.</p></bio><bio xml:lang="en"><p>MD</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НУО «Казахстанско-Российский медицинский университет»<country>Казахстан</country></aff><aff xml:lang="en">NEI «Kazakh-Russian Medical University»<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>01</day><month>11</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>53</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Фазылов Т.Р., Дуйсенов Н.Б., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Фазылов Т.Р., Дуйсенов Н.Б.</copyright-holder><copyright-holder xml:lang="en">Fazylov T.R., Duisenov N.B.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://kazrosmedjournal.krmu.edu.kz/jour/article/view/130">https://kazrosmedjournal.krmu.edu.kz/jour/article/view/130</self-uri><abstract><p>Введение. Терапия обогащенной тромбоцитами и лейкоцитами плазмой (PRP) - это современный метод, который использует аутологичную плазму для улучшения и ускорения за живления костей.Цель. Для определения уровня безопасности и эффективности методики используют плазму, обогащенную тромбоцитами и лейкоцитами.Материалы и методы. Поиск проводился с использованием баз данных PubMed, Cochrane и Web of Science. Поиск осуществлялся по ключевым словам без языковых ограничений .Актуальность. Терапия костных дефектов является серьезной проблемой для врача-травматолога. Костные дефекты часто развиваются при тяжелой травме или в результате больших объемных резекций в результате таких патологий, как опухоли или костная инфекция.Вывод. Несмотря на существующие преимущества, использование технологии PRP не является полностью оправданным. Необходимо провести еще много качественных клинических испытаний, которые окончательно поставят крест на эффективности метода.</p></abstract><trans-abstract xml:lang="en"><p>Background. Platelet and white blood cell rich plasma (PLRP) therapy is a newly developed method that uses autologous plasma to improve and accelerate bone healing.Purpose. To determine the level of safety and effectiveness of the technique using plasma enriched with platelets and white blood cells.Materials and methods. A search was performed using PUBMED, Cochrane, and web of Science databases. The search was performed using keywords with no language restrictions.Relevance. Therapy in bone defects is a serious challenge for a trauma Clinician. Bone defects often develop with severe trauma or as a result of large volume resections as a result of pathologies such as tumors or bone infection.Conclusion. Despite the existing advantages, the use of PLRP technology is not fully justified. It is necessary to perform many more high-quality clinical trials that will finally put an end to the effectiveness of the method.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>обогащенная тромбоцитами плазма</kwd><kwd>костный трансплантат</kwd><kwd>восстановление костей</kwd><kwd>графты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>platelet-rich plasma</kwd><kwd>bone graft</kwd><kwd>bone repair</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Berner A. [и др.]. Biomimetic tubular nanofiber mesh and platelet rich plasma-mediated delivery of BMP- 7 for large bone defect regeneration // Cell and Tissue Research. 2012.</mixed-citation><mixed-citation xml:lang="en">Berner A. [и др.]. 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