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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medinfo</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальные проблемы теоретической и клинической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Actual Problems of Theoretical and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2790-1289</issn><issn pub-type="epub">2790-1297</issn><publisher><publisher-name>Казахстанско-Российский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24412/2790-1289-2022-4-4245</article-id><article-id custom-type="elpub" pub-id-type="custom">medinfo-251</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES</subject></subj-group></article-categories><title-group><article-title>Эмпирическая терапия у мужчин с нарушением репродуктивной функции, перенесших микрохирургическую субингвинальную варикоцелэктомию</article-title><trans-title-group xml:lang="en"><trans-title>Empirical therapy in men with impaired reproductive function who underwent microsurgical subinguinal varicocelectomy</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3584-7231</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бримжаров</surname><given-names>Т. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Brimzharov</surname><given-names>T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Талгат Бауржанович Бримжаров, к. м. н.</p><p>Алматы</p></bio><bio xml:lang="en"><p>Talgat Brimzharov</p><p>Almaty</p></bio><email xlink:type="simple">talgatbb@yandex.kz</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-7034-3605</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Джамбулова</surname><given-names>Б. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Dzhambulova</surname><given-names>B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бела Тельмановна Джамбулова, к. м. н., доцент</p><p>Алматы</p></bio><bio xml:lang="en"><p>Bela Dzhambulova</p><p>Almaty</p></bio><email xlink:type="simple">uro-krmu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2201-402X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Муханов</surname><given-names>Н. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Mukhanov</surname><given-names>N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нурлан Елжанович Муханов </p><p>Алматы</p></bio><bio xml:lang="en"><p>Nurlan Mukhanov</p><p>Almaty</p></bio><email xlink:type="simple">uro-krmu@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НУО «Казахстанско-Российский медицинский университет»<country>Казахстан</country></aff><aff xml:lang="en">NEI «Kazakh-Russian Medical University»<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>13</day><month>12</month><year>2022</year></pub-date><volume>0</volume><issue>4</issue><fpage>42</fpage><lpage>45</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Бримжаров Т.Б., Джамбулова Б.Т., Муханов Н.Е., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Бримжаров Т.Б., Джамбулова Б.Т., Муханов Н.Е.</copyright-holder><copyright-holder xml:lang="en">Brimzharov T., Dzhambulova B., Mukhanov N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://kazrosmedjournal.krmu.edu.kz/jour/article/view/251">https://kazrosmedjournal.krmu.edu.kz/jour/article/view/251</self-uri><abstract><p>   В Казахстане на долю мужского бесплодия отводится от 30 % до 45 % случаев. В основе патогенеза снижения фертильности у пациентов с варикоцеле лежит термическое воздействие, что часто сопровождается олигозооспермией и астенозооспермией. Одним из часто используемых методов лечения в послеоперационном периоде у пациентов с нарушением фертильности и варикоцеле применяются антиэстрогены, так как они входят в обратную связь половых стероидов на уровне гипоталамуса и гипофиза, повышая выработку эндогенного гонадотропин-рилизинг гормона гипоталамусом и, соответственно, ЛГ и ФСГ гипофизом.</p></abstract><trans-abstract xml:lang="en"><p>   In Kazakhstan, male infertility accounts for 30 % to 45 % of cases. The pathogenesis of fertility decline in patients with varicocele is based on thermal exposure, which is often accompanied by oligozoospermia and asthenozoospermia. One of the most frequently used methods of treatment in the postoperative period in patients with impaired fertility and varicocele, antiestrogens are used, since they enter into the feedback of sex steroids at the level of the hypothalamus and pituitary gland, increasing the production of endogenous gonadotropin-releasing hormone by the hypothalamus and, respectively, LH and FSH by the pituitary gland.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>варикоцеле</kwd><kwd>микрохирургическая субингвинальная варикоцелэктомия</kwd><kwd>мужское бесплодие</kwd><kwd>антиэстрогены</kwd><kwd>тамоксифен</kwd></kwd-group><kwd-group xml:lang="en"><kwd>varicocele</kwd><kwd>microsurgical subinguinal varicocelectomy</kwd><kwd>male infertility</kwd><kwd>antiestrogens</kwd><kwd>tamoxifen</kwd></kwd-group><funding-group xml:lang="ru"><funding-statement>Финансирование отсутствует</funding-statement></funding-group><funding-group xml:lang="en"><funding-statement>Financing absent</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Мазо Е. 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