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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medinfo</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальные проблемы теоретической и клинической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Actual Problems of Theoretical and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2790-1289</issn><issn pub-type="epub">2790-1297</issn><publisher><publisher-name>Казахстанско-Российский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24412/2790-1289-2023-1-65-72</article-id><article-id custom-type="elpub" pub-id-type="custom">medinfo-293</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVEWS</subject></subj-group></article-categories><title-group><article-title>НОВЫЙ ПРОТИВОТУБЕРКУЛЕЗНЫЙ ПРЕПАРАТ ПРЕТОМАНИД ДЛЯ ЛЕЧЕНИЯ ЛЕКАРСТВЕННО-УСТОЙЧИВОГО ТУБЕРКУЛЕЗА (ОБЗОР)</article-title><trans-title-group xml:lang="en"><trans-title>A NEW ANTI-TUBERCULOSIS DRUG PRETOMANID FOR THE TREATMENT OF DRUG-RESISTANT TB (REVIEW)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5312-1111</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Смаилова</surname><given-names>Г. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Smailova</surname><given-names>G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Смаилова Гульнара Аскаровна, доктор медицинских наук, профессор</p><p>Алматы</p></bio><bio xml:lang="en"><p>Smailova Gulnara, MD, Professor</p><p>Almaty</p></bio><email xlink:type="simple">gsmailova@yndex.kz</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НУО «Казахстанско-Российский медицинский университет»<country>Казахстан</country></aff><aff xml:lang="en">NEI «Kazakhstan-Russian Medical University»<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>27</day><month>04</month><year>2023</year></pub-date><volume>0</volume><issue>1</issue><fpage>65</fpage><lpage>72</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Смаилова Г.А., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Смаилова Г.А.</copyright-holder><copyright-holder xml:lang="en">Smailova G.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://kazrosmedjournal.krmu.edu.kz/jour/article/view/293">https://kazrosmedjournal.krmu.edu.kz/jour/article/view/293</self-uri><abstract><p>В обзоре использовано 61 источников литературы, посвященных новому противотуберкулезному препарату PA-824-претоманиду, который проявляет антимикробную активность против штаммов микобактерии туберкулеза с лекарственной устойчивостью. Согласно изученным данным, комбинации претоманида с другими химиопрепаратами высокоэффективны и перспективны при проведении лечения пациентов с лекарственно-устойчивым туберкулезом.</p></abstract><trans-abstract xml:lang="en"><p>The review used 61 literature sources on the new anti-tuberculosis drug PA-824-pretomanid, which exhibits antimicrobial activity against strains of drug-resistant Mycobacterium tuberculosis. According to the studied data, combinations of pretomanid with other chemotherapy drugs are highly effective and promising in the treatment of patients with drug-resistant tuberculosis.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулез</kwd><kwd>лекарственно-устойчивый туберкулез</kwd><kwd>претоманид</kwd><kwd>противотуберкулезные препараты</kwd><kwd>химиотерапия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tuberculosis</kwd><kwd>drug-resistant tuberculosis</kwd><kwd>pretomanid</kwd><kwd>anti-tuberculosis drugs</kwd><kwd>chemotherapy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ваксман Зельман Абрахам. Википедия. [Электронный ресурс. URL: https: //ru.wikipedia.org/wiki/%D0%92%D0%B0%D0%BA%D1%81%D0%BC%D0%B0%D0%BD,_%D0%97%D0%B5%D0%BB%D1%8C%D0%BC%D0%B0%D0%BD_%D0%90%D0%B1%D1%80%D0%B0%D1%85%D0%B0%D0%BC. [Vaksman Zel'man Abraham. 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