medinfoАктуальные проблемы теоретической и клинической медициныActual Problems of Theoretical and Clinical Medicine2790-12892790-1297Казахстанско-Российский медицинский университет10.24412/2790-1289-2024-1-35-42medinfo-409Research ArticleОБЗОР ЛИТЕРАТУРЫREVEWSПатогенетические аспекты хронической сердечной недостаточности с сохраненной фракцией выбросаPathogenetic aspects of chronic heart failure with preserved ejection fractionhttps://orcid.org/0000-0001-9202-7451ТундыбаеваМ. К.TundybayevaМ. К.

Тундыбаева Мейрамгуль Капсиметқызы – д.м.н., ассоц.профессор,

г. Алматы.

Almaty.

mira_2828@mail.ruhttps://orcid.org/0009-0002-3983-2747ТөлешГ. Қ.ToleshG. К.

Төлеш Гүлзина Қызырқызы – магистрант 2 года обучения,

г. Алматы.

Almaty.

gulzinatolesh@gmail.comНУО «Казахстанско-Российский медицинский университет»КазахстанKazakh-Russian Medical UniversityKazakhstan202420052024014456Copyright © Тундыбаева М.К., Төлеш Г.Қ., 20242024Тундыбаева М.К., Төлеш Г.Қ.Tundybayeva М.К., Tolesh G.К.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://kazrosmedjournal.krmu.edu.kz/jour/article/view/409

Цель. Хроническая сердечная недостаточность представляет собой один из наиболее часто встречающихся синдромов сердечно-сосудистой системы, влияющий на функцию и анатомию сердца. На сегодняшний день в здравоохранении проблема высокой распространенности хронической сердечной недостаточности с сохраненной фракцией выброса играет существенную роль в летальности пациентов. Высокий риск осложнений, нарушение жизненно важных функций организма неизбежно снижают качество жизни пациентов. В связи с проблемой высокой распространенности хронической сердечной недостаточности мы проанализировали литературные источники по данной теме.Методы. В статье по данным обзора литературы представлены данные о патогенетических аспектах хронической сердечной недостаточности с сохраненной фракцией выброса.Результаты. Доказана роль следующих факторов: диастолическая дисфункция, миокардиальный фиброз, оксидативный стресс и воспаление, эндотелиальная дисфункция и т.д.Выводы. Патогенез хронической сердечной недостаточности с сохраненной фракцией выброса многогранен, включает в себя множество составляющих. Сердца пациентов с хроническойсердечной недостаточности с сохраненной фракцией выброса претерпевают гипертрофическую форму ремоделирования и у большинства пациентов с хронической сердечной недостаточности ссохраненной фракцией выброса есть признаки диастолической дисфункции. Изучение патогенетических механизмов развития хронической сердечной недостаточности с сохраненной фракциейвыброса может помочь в дальнейшем поиске новых терапевтических стратегий.

Purpose. Chronic heart failure (CHF) is one of the most common syndromes of thecardiovascular system (CVS) that affects the function and anatomy of the heart. Currently, the issue of the high prevalence of chronic heart failure with preserved ejection fraction (HFpEF) plays a significant role in patient mortality in healthcare. The high risk of complications and disruption of vital functionsinevitably reduces the quality of life for patients. Due to the problem of the high prevalence of chronic heart failure, we analyzed the literature on this topic.Methods. The article presents data on the pathogenetic aspects of HFpEF based on a literature review.Results. The role of factors such as diastolic dysfunction, myocardial fibrosis, oxidative stress, inflammation, endothelial dysfunction, etc., has been proven.Conclusions. Thus, the pathogenesis of HFpEF is multifaceted and includes many components.The hearts of patients with HFpEF undergo hypertrophic remodeling, and most HFpEF patients exhibit signs of diastolic dysfunction. Studying the pathogenetic mechanisms of HFpEF development can help in the further search for new therapeutic strategies.

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The authors declare that there are no conflicts of interest present.