medinfoАктуальные проблемы теоретической и клинической медициныActual Problems of Theoretical and Clinical Medicine2790-12892790-1297Казахстанско-Российский медицинский университет10.24412/2790-1289-2024-3-46-67medinfo-421Research ArticleОБЗОР ЛИТЕРАТУРЫREVEWSНовый подход к медицинской реабилитации и паллиативной помощи пациентам с онкопатологией в контексте интегративной медициныA new approach to medical rehabilitation and palliative care for patients with oncology in the context of integrative medicinehttps://orcid.org/0000-0003-0596-8777ПановС. А.PanovS. A.

Панов Станислав Александрович – к.м.н., д.ф. (PhD), профессор

Panov Stanislav Alexandrovich – Candidate of Medical Sciences, PhD, Professor

panov_stanislav@mail.ruhttps://orcid.org/0009-0005-1660-5439БалтабековН. Т.BaltabekovN. T.

Балтабеков Нурлан Турсунович – д.м.н., профессор

Baltabekov Nurlan Tursunovich – Doctor of Medical Sciences, Professor

baltabekov@mail.ruhttps://orcid.org/0009-0007-6098-8056ПавлюковА. В.PavlyukovA. V.

Павлюков Андрей Викторович

Pavlyukov Andrey Viktorovich

andrei19791508@mail.ruhttps://orcid.org/0000-0002-4051-0908ПалтушевА. А.PaltushevA. A.

Палтушев Абдували Абдумухаметович

Paltushev Abduvali Abdumukhametovich

pal2sheff@hotmail.comНургалиевБ. Э.NurgalievB. E.

Нургалиев Бауржан Эсенгельдиевич

Nurgaliev Baurzhan Esengeldievich

Nurgaliev-b@hotmail.comhttps://orcid.org/0009-0000-6501-5033РысбаевА. В.RysbaevA. V.

Рысбаев Аскар Васильевич

Rysbaev Askar Vasilyevich

rysbaev-a@hotmail.comВоенный клинический госпиталь Министерства обороны Республики КазахстанКазахстанMilitary Clinical Hospital of the Ministry of Defense of the Republic of KazakhstanKazakhstanНаучно-исследовательский международный институт последипломного образованияКазахстанInternational Research Institute of Postgraduate EducationKazakhstanВоенно-медицинское управление Министерства обороны Республики КазахстанКазахстанMilitary Medical Department of the Ministry of Defense of the Republic of KazakhstanKazakhstanГлавный Военный клинический госпиталь Министерства обороны Республики КазахстанКазахстанThe Main Military Clinical Hospital of the Ministry of Defense of the Republic of KazakhstanKazakhstan202402092024034666Copyright © Панов С.А., Балтабеков Н.Т., Павлюков А.В., Палтушев А.А., Нургалиев Б.Э., Рысбаев А.В., 20242024Панов С.А., Балтабеков Н.Т., Павлюков А.В., Палтушев А.А., Нургалиев Б.Э., Рысбаев А.В.Panov S.A., Baltabekov N.T., Pavlyukov A.V., Paltushev A.A., Nurgaliev B.E., Rysbaev A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://kazrosmedjournal.krmu.edu.kz/jour/article/view/421

В систематическом обзоре обобщены современные исследования влияния растительных фенолов и некоторых лекарственных препаратов на внутриклеточный биохимический каскад в процессе формирования противоракового иммунитета. Кроме того, в нем исследуются потенциальные клинически доступные методы оценки иммунитета, которые могут быть применены в контексте интегративной медицины для персонализации реабилитационной терапии онкологических больных после химиотерапии и хирургического вмешательства.Глубина поиска составляет 6 лет (с 2017 г. до 2023 г.). В поиск включены исследования из рецензируемых журналов и не рецензируемых публикаций. Систематический обзор в основном включает фундаментальные исследования и обзорные статьи, размещенные в шести электронных базах данных: PubMed/MEDLINE, Кокрейновская библиотека, Science Direct, Google Scholar, eLIBRARY, Web of Science.В результате отобраны 64 исследования, из которых 29 были оригинальными (11 исследований на животных, 8 исследований на клеточных культурах и 10 исследований на 1344 взрослых людях). Для правильного подбора схемы питания и восстановительной терапии очень важнообращать внимание на состояние физиологического стресса, степень дисфункции митохондрий, количественное и качественное состояние нейтрофилов и лимфоцитов. На основании этих показателей можно достоверно персонализировать дозы, сроки терапии и контролировать эффективность. Оказалось, что иммунная система устроена еще сложнее, чем нервная и функциональная активность лейкоцитов может отражать также и гомеостаз всего внутреннего мира человека, а по состоянию функции гранулоцитов можно судить о функции большинства клеток целого организма и оценивать «иммунологический контроль опухоли» в ключе состояния «микроокружения опухоли», предложенный Eggermont AMM

The systematic review summarizes modern studies of the effect of plant phenols and certain drugs on the intracellular biochemical cascade in the formation of anti-cancer immunity. In addition, it explores potential clinically available methods for assessing immunity that can be applied in the context of integrative medicine to personalize rehabilitation therapy for cancer patients after chemotherapy and surgery.The search depth is 6 years (from 2017 to 2023). The search includes research from peer-reviewed journals and non-peer-reviewed publications. The systematic review mainly includes basic research and review articles published in six electronic databases: PubMed/MEDLINE (https://pubmed.ncbi.nlm.nih.gov/), The Cochrane Library (https://www.cochranelibrary.com/), ScienceDirect (https://www.sciencedirect.com/), Google Scholar (https://scholar.google.com.mx /), eLibrary (https://elibrary.ru/), Web of Science (https://www.webofscience.com/).As a result, 64 studies were selected, of which 29 were original (11 animal studies, 8 cell culture studies and 10 studies on 1,344 adults).Conclusions. For the correct selection of a nutrition regimen and rehabilitation therapy, it is very important to pay attention to the state of physiological stress, the degree of mitochondrial dysfunction, the quantitative and qualitative state of neutrophils and lymphocytes. Based on these indicators, it is possible to reliably personalize the dose, the duration of therapy and monitor the effectiveness. It turned out that the immune system is even more complicated than the nervous and functional activity of leukocytes can also reflect the homeostasis of the entire inner world of a person, and according to the state of granulocyte function, it is possible to judge the function of most cells of the whole organism and evaluate the «immunological control of the tumor» in the key of the state of the "tumor microenvironment" proposed by Eggermont AMM.

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The authors declare that there are no conflicts of interest present.