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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medinfo</journal-id><journal-title-group><journal-title xml:lang="ru">Актуальные проблемы теоретической и клинической медицины</journal-title><trans-title-group xml:lang="en"><trans-title>Actual Problems of Theoretical and Clinical Medicine</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2790-1289</issn><issn pub-type="epub">2790-1297</issn><publisher><publisher-name>Казахстанско-Российский медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.24412/2790-1289-2021-33941</article-id><article-id custom-type="elpub" pub-id-type="custom">medinfo-44</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОР ЛИТЕРАТУРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVEWS</subject></subj-group></article-categories><title-group><article-title>ИНГИБИТОРЫ ПРОТОННОЙ ПОМПЫ (ИПП) КАК ФАКТОРЫ ПОВЫШЕННОГО РИСКА ЗАРАЖЕНИЯ КОРОНАВИРУСНОЙ ИНФЕКЦИИ COVID-19 (SARS COV-2) (ОБЗОР)</article-title><trans-title-group xml:lang="en"><trans-title>PROTON PUMP INHIBITORS (PPIs) AS FACTORS OF INCREASED RISK OF COVID-19 CORONAVIRAL INFECTION (review)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жангабылов</surname><given-names>А. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Zhangabylov</surname><given-names>A. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор</p></bio><bio xml:lang="en"><p>MD, Professor</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тастемирова</surname><given-names>К. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Tastemirova</surname><given-names>K. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>Candidate of Medical Sciences</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кудабаева</surname><given-names>В. Ж.</given-names></name><name name-style="western" xml:lang="en"><surname>Kudabaeva</surname><given-names>V. Zh.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач терапевт</p></bio><bio xml:lang="en"><p>therapist</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru">НУО «Казахстанско-Российский Медицинский Университет»<country>Казахстан</country></aff><aff xml:lang="en">NEI «Kazakh-Russian Medical University»<country>Kazakhstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>17</day><month>10</month><year>2022</year></pub-date><volume>0</volume><issue>3</issue><fpage>39</fpage><lpage>41</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Жангабылов А.К., Тастемирова К.К., Кудабаева В.Ж., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Жангабылов А.К., Тастемирова К.К., Кудабаева В.Ж.</copyright-holder><copyright-holder xml:lang="en">Zhangabylov A.K., Tastemirova K.K., Kudabaeva V.Z.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://kazrosmedjournal.krmu.edu.kz/jour/article/view/44">https://kazrosmedjournal.krmu.edu.kz/jour/article/view/44</self-uri><abstract><p>В данной работе отражены ингибиторы протонной помпы, которые на сегодняшний день относятся к наиболее часто назначаемым средствам в гастроэнтерологии, во всем мире. Влияние ИПП на тяжесть клинического течения COVID-19 инфекции у пациентов.Задача: Определить влияние ИПП на тяжесть клинического течения COVID-19 инфекции у пациентов.Влияние ИПП на восприимчивость к SARS-COV-2. Ингибиторы протонной помпы удваивают риск заражения коронавирусной инфекцией и являются одним из факторов заражения COVID-19.Анализ полученных данных показал, что использование ИПП связано с повышенным риском положительного теста на коронавирус, как уже отмечалось. По сравнению с респондентами, которые не используют эти препараты, у принимавших ИПП раз или два раза в день.</p></abstract><trans-abstract xml:lang="en"><p>This work reflects proton pump inhibitors, which today are among the most commonly prescribed drugs in gastroenterology around the world. Impact of PPIs on the severity of the clinical course of COVID-19 infection in patients.Objective: To determine the effect of PPIs on the severity of the clinical course of COVID-19 infection in patients.The effect of PPIs on susceptibility to SARS-COV-2. Proton pump inhibitors double the risk of contracting coronavirus infection and area contributor to COVID-19 infection.Analysis of the data obtained showed that PPIs use is associated with an increased risk of a positive test for coronavirus, as already noted. Compared to respondents who do not use these drugs, those who used PPIs once or twice a day</p></trans-abstract><kwd-group xml:lang="ru"><kwd>Ингибиторы протонной помпы</kwd><kwd>коронавирусная инфекция</kwd><kwd>пантопразол</kwd><kwd>рабепразол</kwd><kwd>соляная кислота</kwd><kwd>риск заражения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>proton pump inhibitors</kwd><kwd>coronavirus infection</kwd><kwd>pantoprazole</kwd><kwd>rabeprazole</kwd><kwd>hydrochloric acid</kwd><kwd>risk of infection</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Aby E.S., Rodin H., Debes J.D. Proton Pump Inhibitors and Mortality in Individuals With COVID-19. Am J. Gastroenterol. 2020 Nov;115(11):</mixed-citation><mixed-citation xml:lang="en">Aby E.S., Rodin H., Debes J.D. Proton Pump Inhibitors and Mortality in Individuals With COVID-19. Am J. 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