medinfoАктуальные проблемы теоретической и клинической медициныActual Problems of Theoretical and Clinical Medicine2790-12892790-1297Казахстанско-Российский медицинский университет10.24412/2790-1289-2025-2-35-56medinfo-712Research ArticleОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯORIGINAL ARTICLESНАРУШЕНИЕ ВЕГЕТАТИВНОЙ РЕГУЛЯЦИИ У ПОЖИЛЫХ ПАЦИЕНТОВ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ И ПОСТКОВИДНЫМ СИНДРОМОМAUTONOMIC REGULATION DISORDERS IN ELDERLY PATIENTS WITH ARTERIAL HYPERTENSION AND POST-COVID SYNDROMEhttps://orcid.org/0009-0004-6569-0484ТастайбекТ. А.TastaibekT. A.

Тастайбек Тимур Аманжолұлы – магистрант 2 года кафедры «Общая врачебная практика

Алматы

Tastaibek Timur Amanzholuly – 2nd-year master’s student, department of general medical practice

Almaty

tasstaibek@mail.ruhttps://orcid.org/0009-0004-5851-6381КостоусоваМ. А.KostousovaM. A.

Костоусова Мария Алексеевна – магистрант 2 года кафедры «Общая врачебная практика

Алматы

Kostousova Maria Alekseevna – 2nd-year master’s student, department of general medical practice

Almaty

kostousova.maria@bk.ruhttps://orcid.org/0000-0002-1817-9825КудабаеваВ. Ж.KudabaevaV. Z.

 

Кудабаева Венера Жанарбековна – докторант 3 года кафедры «Общая врачебная практика»

Алматы

Kudabaeva Venera Zhanarbekovna – 3rd-year doctoral student, department of general medical practice

Almaty

venera-85-09@mail.ruhttps://orcid.org/0000-0002-5318-0995МаншариповаА. Т.MansharipovaA. T.

Маншарипова Алмагуль Тулеуовна – доктор медицинских наук, профессор кафедры «Общая врачебная практика»

Алматы

Mansharipova Almagul Tuleuovna – doctor of medical sciences, professor, department of general medical practice

Almaty

dralma@mail.ruhttps://orcid.org/0000-0002-4065-8275АдиеваМ. К.AdiyevaM. K.

Адиева Мадина Куангановна – PhD, заведующая кафедры «Общая врачебная практика»

Алматы

Adiyeva Madina Kuanganovna – PhD, head of the department of general medical practice

Almaty

m.adiyeva@yandex.ruНУО «Казахстанско-Российский медицинский университет»КазахстанNEI «Kazakhstan-Russian Medical University»Kazakhstan202506072025023556Copyright © Тастайбек Т.А., Костоусова М.А., Кудабаева В.Ж., Маншарипова А.Т., Адиева М.К., 20252025Тастайбек Т.А., Костоусова М.А., Кудабаева В.Ж., Маншарипова А.Т., Адиева М.К.Tastaibek T.A., Kostousova M.A., Kudabaeva V.Z., Mansharipova A.T., Adiyeva M.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://kazrosmedjournal.krmu.edu.kz/jour/article/view/712

Постковидный синдром у пожилых пациентов с артериальной гипертензией остаётся недостаточно изученным, особенно в аспекте вегетативной дисфункции. Системное воздействие SARSCoV-2 и его влияние на регуляцию сердечно-сосудистой системы делают выявление таких нарушений актуальной задачей современной медицины.

Цель исследования

Цель исследования. Изучение нарушений функции вегетативной нервной системы у пожилых пациентов с артериальной гипертензией и постковидным синдромом.

Материалы и методы

Материалы и методы. В рамках амбулаторного наблюдения на клинических базах Казахстанско-Российского медицинского университета проведено исследование вегетативных нарушений у пожилых пациентов с артериальной гипертензией и постковидным синдромом. Обследование включало опрос, физикальный осмотр, анкетирование по шкале А. М. Вейна и анализ вариабельности сердечного ритма с использованием модуля «КардиоВизор». Оценивались временные и спектральные параметры: SDNN, rMSSD, pNN50, LF, HF, LF/HF, индекс напряжения и показатель активности регуляторных систем.

Результаты

Результаты. В исследование включён 141 пациент, разделённый на две группы. Средний возраст в основной группе составил 70,81 ± 5,36 года, в контрольной – 74,00 ± 6,06 года (p = 0,003). Доля пациентов 60-74 лет была выше в основной группе (p = 0,006). Артериальная гипертензия 1 степени чаще встречалась у пациентов с постковидным синдромом, 2 и 3 степени – у контрольной группы (p = 0,042). У пациентов с постковидным синдромом преобладали слабость (38,36 %), тревожность (19,18 %), снижение памяти (21,92 %) и потливость (26,03 %) (p ≤ 0,001). По шкале Вейна отмечено преобладание респираторных симптомов при волнении (p = 0,014). Среди показателей вариабельности сердечного ритма достоверно различалось отношение LF/HF (1,8 против 1,5; p = 0,049).

Вывод

Вывод. У пожилых пациентов с артериальной гипертензией постковидный синдром сопровождается характерными жалобами и признаками вегетативной дисфункции, что требует дальнейшего изучения влияния на хронические заболевания.

Post-COVID syndrome in elderly patients with arterial hypertension remains insufficiently studied, particularly in terms of autonomic dysfunction. The systemic effects of SARS-CoV-2 and its influence on cardiovascular regulation make the identification of such disorders a relevant issue in modern medicine.

Objective of the Study

Objective of the Study. To investigate autonomic nervous system dysfunction in elderly patients with arterial hypertension and post-COVID syndrome.

Materials and мethods

Materials and мethods. As part of outpatient follow-up at the clinical bases of the Kazakhstan Russian Medical University, a study was conducted to assess autonomic dysfunction in elderly patients with arterial hypertension and post-COVID syndrome. The examination included interviews, physical examinations, and assessment using Wayne’s scale, and heart rate variability analysis using the «CardioVisor» module. Time and frequency domain parameters were evaluated: SDNN, rMSSD, pNN50, LF, HF, LF/HF, the stress index, and the regulatory systems activity index.

Results

Results. The study included 141 patients divided into two groups. The mean age in the main group was 70.81 ± 5.36 years, compared to 74.00 ± 6.06 years in the control group (p = 0.003). The proportion of patients aged 60-74 years was higher in the main group (p = 0.006). Grade 1 arterial hypertension was more common in patients with post-COVID syndrome, while grades 2 and 3 were more frequent in the control group (p = 0.042). Patients with post-COVID syndrome more often reported fatigue (38.36 %), anxiety (19.18 %), memory impairment (21.92 %), and excessive sweating (26.03 %) (p ≤ 0.001). According to the Wayne scale, respiratory symptoms were more prevalent during emotional stress (p = 0.014). Among heart rate variability indicators, a significant difference was observed in the LF/HF ratio (1.8 vs 1.5; p = 0.049).

Conclusion

Conclusion. In elderly patients with arterial hypertension, post-COVID syndrome is accompanied by characteristic complaints and signs of autonomic dysfunction, highlighting the need for further investigation into its impact on chronic conditions.

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The authors declare that there are no conflicts of interest present.