STRESS AND GENERAL ADAPTATION SYNDROME, THE ROLE OF STRESS IN PATHOLOGY

The General adaptive syndrome develops as a non-specific and specific response mainly to the influence of a conditioned factor against the background of a target stimulatory generalized reaction. In the future, during the development of the stress response, a functional system has developed that contributes to adaptation or normal life by withstanding the pathogenic effects of an emergency factor.
G. Selye was the first to discover the systemic stereotypical response of the body (stress) to the effects (stressors) of the external and internal environment, threatening to disrupt homeostasis and develop pathology. It was only G. Selye who managed to combine all these phenomena into a single syndrome and understand their biological meaning. In addition to the neural component of the response, it has proven to involve the endocrine and immune systems. In this regard, it can be argued that it Was G. Selye who was at the origin of modern ideas about the unified neuroimmune – endocrine regulation of body functions in normal and pathological conditions.

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