A new approach to medical rehabilitation and palliative care for patients with oncology in the context of integrative medicine

The systematic review summarizes modern studies of the effect of plant phenols and certain drugs on the intracellular biochemical cascade in the formation of anti-cancer immunity. In addition, it explores potential clinically available methods for assessing immunity that can be applied in the context of integrative medicine to personalize rehabilitation therapy for cancer patients after chemotherapy and surgery.
The search depth is 6 years (from 2017 to 2023). The search includes research from peer-reviewed journals and non-peer-reviewed publications. The systematic review mainly includes basic research and review articles published in six electronic databases: PubMed/MEDLINE (https://pubmed.ncbi.nlm.nih.gov/), The Cochrane Library (https://www.cochranelibrary.com/), ScienceDirect (https://www.sciencedirect.com/), Google Scholar (https://scholar.google.com.mx /), eLibrary (https://elibrary.ru/), Web of Science (https://www.webofscience.com/).
As a result, 64 studies were selected, of which 29 were original (11 animal studies, 8 cell culture studies and 10 studies on 1,344 adults).
Conclusions. For the correct selection of a nutrition regimen and rehabilitation therapy, it is very important to pay attention to the state of physiological stress, the degree of mitochondrial dysfunction, the quantitative and qualitative state of neutrophils and lymphocytes. Based on these indicators, it is possible to reliably personalize the dose, the duration of therapy and monitor the effectiveness. It turned out that the immune system is even more complicated than the nervous and functional activity of leukocytes can also reflect the homeostasis of the entire inner world of a person, and according to the state of granulocyte function, it is possible to judge the function of most cells of the whole organism and evaluate the «immunological control of the tumor» in the key of the state of the "tumor microenvironment" proposed by Eggermont AMM.

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