COMPARATIVE CHARACTERISTICS OF ANTIOXIDANT ACTIVITY OF DIHYDROQ UERCETIN, VITAMIN C, NEPHROMONE PLUS, VALEMIDINE PLUS, POLYOXIDONIUM

The problem of preserving health and increasing human life expectancy is considered one of the most urgent. In the body, under normal conditions, proteins, lipids and nucleic acids are constantly being updated by peroxidation. The activity of this process is controlled by antioxidants that can effectively interact with free radicals. One of the links in the pathogenesis of various diseases is oxidative stress, namely activation of peroxidation and depletion of the system of endogenous antioxidants. The use of antioxidants for therapeutic and preventive purposes is discussed in the medical literature. In the arsenal of means that limit the activity of free radical oxidation, there are synthetic drugs and herbal medicines. The paper presents a comparative characteristic of the antioxidant activity of some drugs used in therapeutic and preventive practice.

1. Aliev O.I., Sidehmenova A.V., Shamanaev A.Ju., i dp. Mehanizmy gipotenzivnogo dejstvija digidrokvercetina pri arterial'noj gipertenzii. //Bjull.jeksp.biologii i mediciny. 2016. № 9.S. 75-78. (in Russian)

2. Boldsajhan B. Mongol orny jemijn urgamlyn njevtjerhij tol'. Mongol ulsyn shinzhljeh uhaan, tehnologijn ih surguulijn. Ulaanbaatar, 2004; 274. (in Russian)

3. Velichkovska L.N., Soljonova E.A. Vlijanie preparata «Nefromon» na dinamiku biogennyh aminov pri hronicheskom pielonefrite. Acta medica Eurasica 2017; 3: 18‐24. (in Russian)

4. Ibn Sina (Avicenna). Kanon vrachebnoj nauki. Izd. Akademii nauk Uzbekskoj SSR. Tashkent 1960: T.V; 21, 23, 27, 107, 135, 159, 160, 166, 222, 226. [Ibn-sina-(avicenna). Kanon vrachebnoj nauki. Izd.akademii nauk uzbekskoj ssr. Tashkent 1960: T.V; 21, 23, 27, 107, 135, 159, 160, 166, 222, 226]. (in Russian)

5. Konkina I.G., Grabovskij S.A., Murinov Ju.I., i dp Sravnitel'naja ocenka reakcionnoj sposobnosti kvercetina i digidrokvercetina po otnosheniju k peroksil'nym radikalam // Himija rastit. syr'ja. - 2011. - No3. - S. 2070 - 2086. (in Rusian)

6. Leont'eva N.V., Gerbekova I.D., Borlakova L.M., i dp. Nefroprotektivnye svojstva fitokompleksa na osnove kasatika tonkolistnogo. // Nefrologija. 2018. № 3. T.22. S.65-71. (in Russian)

7. Leont'eva N.V. Bioflavonoidy i ih znachenie v medicine. // Sb. Aktual'nye voprosy vnutrennih boleznej. SPb. 2015. S.64-65. (in Russian)

8. Leont'eva N.V. Digidrokvercetin – prirodnyj antioksidant. Uchebnoe posobie. // SZGMU. 2013. 30 s. (in Russian)

9. Ligaa U. Mongolyn ulamzhilt jemnjeljegt jemijn urgamlyg hjerjegljeh arga ba zhor (Lekarstvennye rastenija i recepty iz rastitel'nogo syr'ja, primenjaemye v mongol'skoj tradicionnoj medicine). Ulan‐Bator 1997; (2): 395. (in Russian).

10. Sarieva K.V., Ljanguzov A.Ju., Galkina O.V., Vetrovoj O.V. Vlijanie tjazheloj gipoksii na HIF1 i Nrf2-oposredovannye mehanizmy antioksidantnoj zashhity v neokortekse krys. // Nejrohimija 2019. T.36. № 2. S.128-139. (in Russian)

11. Tarahovskij Ju.S., Kim Ju.A., Abdrasilov B.S., i dp. Flavonoidy: biohimija, biofizika, medicina. - Synchrobook. Pushhino. 2013. 308 s. (in Russian)

12. Trineeva O.V. Metody opredelenija antioksidantnoj aktivnosti ob#ektov rastitel'nogo i sinteticheskogo proishozhdenija v farmacii. // Razrabotka i registracija lekarstvennyh sredstv. 2017. № 4 (21). 180=197. (in Russian)

13. Tjukavkina N.A., Kolesnik Ju.A., Rulenko I.A., i dp. Digidrokvercetin kak antioksidant // Tezisy II Rossijskogo Nac. Kongressa «Chelovek i lekarstvo», M. - 1995. - S. 295. (in Russian)

14. Tjukavkina N.A., Hutorjanskij V.A., Bazhenov B.N. Sposob poluchenija digidrokvercetina. Pat. № 2091076 Rossija. Opubl. v B.I. 1997 № 27. (in Russian)

15. Hurelbaatar L., Badamcjecjeg B., Gomzhin A.M. i dr. Lekarstvennoe sredstvo s nefroprotektornym dejstviem i sposob ego poluchenija. Patent na izobretenie. Data publikacii 10.12.2014. (in Russian)

16. Choudhary M.I., Nur-e-Alam M., Baig I., Akhtar F., et al. Atta-ur-Rahman.Four new flavones and a new isoflavone from Iris bungei. J Nat Prod. 2001. 64:857–860.

17. Choudhary M.I., Harrem S., Siddiqui H., et al. A benziy and isoflavone Iris tenuifolia. Photochemistry. 2008. 8. 1880-1885.

18. Cui Yan-Mei, Hui Wang, Quan-Ru Liu, et al. Flavans from Iris tenuifollia and their effects on -amiloid aggregation and neural stem cells proliferation in vitro. Bioorganic and Medical Chemistry Letters. 2011. 21. 4400-4403.

19. Haider S.S., Nayar M.S. Arsenic induces oxidative stress, sphingolipidosis, depletes proteins and some antioxidants in various regions of rat brain. Kathmandu Univ Med J. 2008 Jan-Mar;6 (1):60-9.

20. Kohma K., Gombosurengyin P., Ondognyi P., et al. Flavanones from Iris tenuifolia. Phytochemistry. 1997. 44:711–714.

21. Prabhar M.C., Santhikrupa D., ManasaN, et al. Status of free radicals and antioxidants in leprosy patients. Indian Lep.J. 2013 Jan-Mar;85 (1):5-9.

22. Prior R.L., Wu X., and Schaich K., “Standardized methods for the determination of antioxidant capacity and phenolics in foods and dietary supplements”. J Agric Food Chem 53. 4290 - 4302. 2005.

23. Salwa F. / Farag., Yuka Kimura, Hideyuki Ito, et al. New isoflavone glycosides from Iris spuria l. (Calizona) cultivated in Egypt. J.of Natural Medicines. January. 2009. 63-91.

24. Shatar S., Altansetsetseg Sh., Javzmaa N. et al. The Essential Oils of Some Traditional Plants from Mongolia. Materials of the III International Scientific Conference Traditional Medicine: a Current Situation and Perspectives of Development (Ulan‐Ude).2008; 41‐42.

25. Shatar S., Javzmaa N., Radnaeva L.D. et al. Chemotypical Character of the Essential Oils from Some Imported Plants Used in Mongolian Traditional Medicine. Materials of the III International Scientific Conference (Ulan‐Ude). 2008; 43‐44.

26. Zhang Y., Liu L., Yi X., et al. Oxidative stress-induced calreticulin expression and translocation: new insights into the destruction of melanocytes. 2014 Jan;134(1):183-191. doi: 10.1038/jid.2013.268. Epub 2013 Jun 14. J. Invest. Dermatol.