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NORMATIVE FRAMEWORKS AND INTERNATIONAL EVIDENCE ON OCCUPATIONAL WORK UNDER HYPOBARIC HYPOXIA IN HIGH-ALTITUDE

https://doi.org/10.64854/2790-1289-2026-53-3-11

Abstract

Occupational work in high-altitude environments presents a complex array of physiological challenges and health risks due to chronic exposure to hypobaric hypoxia. Prolonged or intermittent stays at altitudes above 2,500 meters place workers at risk of acute mountain sickness, sleep and cognitive disturbances, cardiovascular stress, and long-term complications, including chronic mountain sickness and pulmonary hypertension. Despite shared physiological risks, normative regulatory acts remain heterogeneous across countries and often lag behind contemporary scientific evidence. This variability creates gaps in worker protection, complicates cross-border operations, and hampers surveillance.

Objective. To conduct a comparative analysis of the NLAs of Russia, Kazakhstan, and Kyrgyzstan regulating medical examinations of workers in high-altitude environments, and to assess their concordance with international guidelines and recent evidence.

Materials and Methods. This comparative analysis was conducted through a comprehensive review of national and international normative frameworks, alongside scientific literature and clinical guidelines related to occupational work under hypobaric hypoxia in high-altitude environments. 

Results. The analysis revealed discrepancies between formal lists of contraindications in NLAs and the current evidence based on work under conditions of hypobaric hypoxia. Russia explicitly lists hypobaric hypoxia as a harmful factor but provides general contraindications. Kazakhstan omits hypobaria, while Kyrgyzstan recognizes reduced atmospheric pressure but includes nonspecific contraindications such as hemorrhoids and hernias. International evidence emphasizes cardiovascular, respiratory, hematological, neurological, and ophthalmological risks, while conditions like hemorrhoids lack evidence-based justification.

Conclusion. It is advisable to update the NLAs by highlighting hypobaria as a separate factor and specifying contraindications based on international clinical guidelines. Harmonization with international clinical guidelines (Wilderness Medical Society, ESC, BTS) is necessary to ensure safety and avoid both over-restriction and under-protection.

About the Authors

Akylbek Saktapov
al-Farabi Kazakh National University
Kazakhstan

Senior Lecturer of the Department of Epidemiology, Biostatistics and EBM



Denis Vinnikov
al-Farabi Kazakh National University
Kazakhstan

PhD, Associate Professor, Head of The Environmental Health Lab



Aliya Ualiyeva
al-Farabi Kazakh National University
Kazakhstan

PhD, Associate Professor of the Department of Epidemiology, Biostatistics and EBM



Zhanna Romanova
al-Farabi Kazakh National University
Kazakhstan

PhD, Associate Professor of the Department of Epidemiology, Biostatistics and EBM



Nadira Aitambayeva
Kazakhstan’s Medical University “KSPH”
Kazakhstan

Senior Lecturer of the Department of Public Health and Social Sciences



Laila Nazarova
Kazakhstan’s Medical University “KSPH”
Kazakhstan

Senior Lecturer of the Department of Epidemiology, Biostatistics and EBM



Gani Akhanov
S.D. Asfendiyarov Kazakh National Medical University
Kazakhstan

PhD, Associate Professor



Oryngul Mukanova
Mangystau Central District Hospital
Kazakhstan

Deputy Director for Medical Affairs



References

1. Luks AM, Swenson ER, Bärtsch P. Acute high‑altitude sickness. Eur Respir Rev. 2017;26(143):160096. doi:10.1183/16000617.0096‑2016

2. Bärtsch P, Swenson ER. Clinical practice: acute high‑altitude illnesses. N Engl J Med. 2013;368(24):2294‑2302. doi:10.1056/NEJMcp1214870

3. Naeije R, Vanderpool R. Pulmonary hypertension at high altitude. Eur Respir J. 2019;53(6):1900985. doi:10.1183/13993003.00985‑2019

4. Mairbäurl H, Villafuerte FC. The increase in hemoglobin concentration with altitude: mechanisms and clinical significance. HemaSphere. 2023;7(4):e854. doi:10.1097/HS9.0000000000000854

5. Han C, Xu B, Yang Y, et al. High altitude retinopathy: an overview and new insights. Travel Med Infect Dis. 2024;58:102689. doi:10.1016/j.tmaid.2024.102689

6. Luks AM, Auerbach PS, Freer L, et al. Wilderness Medical Society practice guidelines for the prevention and treatment of acute altitude illness (2019 update). Wilderness Environ Med. 2019;30(4 Suppl):S3‑S18. doi:10.1016/j.wem.2019.04.006

7. Parati G, Agostoni P, Basnyat B, et al. Clinical recommendations for high‑altitude exposure of individuals with pre‑existing cardiovascular conditions. Eur Heart J. 2018;39(17):1546‑1554. doi:10.1093/eurheartj/ehx720

8. Coker RK, Armstrong L, Hart N, et al. British Thoracic Society clinical statement on air travel for passengers with respiratory disease. Thorax. 2022;77(4):329‑350. doi:10.1136/thoraxjnl‑2021‑218110

9. Prikaz Minzdrava Rossii «Ob utverzhdenii Poryadka provedeniya obyazatel'nykh predvaritel'nykh i periodicheskikh meditsinskikh osmotrov rabotnikov, predusmotrennykh chast'yu chetvertoy stat'i 213 Trudovogo kodeksa Rossiyskoy Federatsii, perechnya meditsinskikh protivopokazaniy k osushchestvleniyu rabot s vrednymi i (ili) opasnymi proizvodstvennymi faktorami, a takzhe rabotam, pri vypolnenii kotorykh provodyatsya obyazatel'nye predvaritel'nye i periodicheskie meditsinskie osmotry» ot 28.01.2021 N 29n.

10. Prikaz i.o. Ministra zdravookhraneniya Respubliki Kazakhstan «Ob utverzhdenii tselevykh grupp lits, podlezhashchikh obyazatel'nym meditsinskim osmotram, a takzhe pravil i periodichnosti ikh provedeniya, ob"ema laboratornykh i funktsional'nykh issledovaniy, meditsinskikh protivopokazaniy, perechnya vrednykh i (ili) opasnykh proizvodstvennykh faktorov, professiy i rabot, pri vypolnenii kotorykh provodyatsya predvaritel'nye obyazatel'nye meditsinskie osmotry pri postuplenii na rabotu i periodicheskie obyazatel'nye meditsinskie osmotry i pravil okazaniya gosudarstvennoy uslugi Prokhozhdenie predvaritel'nykh obyazatel'nykh meditsinskikh osmotrov» ot 15.10.2020 goda № ҚR DSM-131/2020

11. Postanovlenie Pravitel'stva Kyrgyzskoy Respubliki «Ob utverzhdenii normativnykh pravovykh aktov Kyrgyzskoy Respubliki v oblasti obshchestvennogo zdravookhraneniya» ot 16.05.2011 № 225

12. Vinnikov D, Tulekov Z, Mustafinov A, et al. Healthy worker survival effect at a high-altitude mine: prospective cohort observation. Sci Rep. 2022;12:14767. doi:10.1038/s41598-022-18331-4

13. Aragón‑Vela J, Sanchez‑Polan M, Morán‑Navarro R, et al. Does intermittent exposure to high altitude increase the risk of cardiovascular disease? A systematic review. BMJ Open. 2020;10(11):e041532. doi:10.1136/bmjopen‑2020‑041532

14. Richalet JP, Hermand E, Lhuissier FJ. Cardiovascular physiology and pathophysiology at high altitude. Nat Rev Cardiol. 2024 Feb;21(2):75-88. doi: 10.1038/s41569-023-00924-9.

15. Sherpa K, Sherpa PP, Sherpa T, et al. Risk of cardiac arrhythmias among climbers on Mount Everest. JAMA Cardiol. 2024;9(5):480‑485. 10.1001/jamacardio.2024.0364

16. Furian M, Hartmann SE, Latshang TD, et al. Acetazolamide to prevent adverse altitude effects in COPD: randomized, double‑blind, placebo‑controlled trial. NEJM Evid. 2022;1(7):EVIDoa2100006. doi:10.1056/EVIDoa2100006

17. Luks AM, Hackett PH. Medical conditions and high‑altitude travel. N Engl J Med. 2022;386(4):364‑373. doi:10.1056/NEJMra2104829

18. Villafuerte FC, Tarazona-Solís P, León-Velarde F. High-altitude erythrocytosis: mechanisms of adaptive and maladaptive responses. Physiology (Bethesda). 2022;37(5):280–292. doi:10.1152/physiol.00029.2021

19. Gordeuk VR, Key NS, Prchal JT. Re-evaluation of hematocrit as a determinant of thrombotic risk in polycythemia and erythrocytosis. Haematologica. 2019;104(4):653–658. doi: 10.3324/haematol.2018.210732

20. Villafuerte FC, Corante N. Chronic Mountain sickness: clinical aspects and management. High Alt Med Biol. 2016;17(2):61‑69. doi:10.1089/ham.2016.0031

21. Duan C, Wu L, at al. Stroke in High-Altitude Areas. Brain Behav. 2025 Jun;15(6):e70626. doi:10.1002/brb3.70626

22. Syed MJ, Khatri IA, at al. Stroke at Moderate and High Altitude. High Alt Med Biol. 2022 Mar;23(1):1-7. doi:10.1089/ham.2021.0043

23. Tu WJ, Xu Y, et al. Impacts of exposure to ambient temperature and altitude on the burden of stroke. J Neurol. 2023 Sep;270(9):4214-4218. doi: 10.1007/s00415-023-11742-x

24. Dangi M, Sadhukhan A, Kumar P, et al. Retinal Manifestations in High Altitude. High Alt Med Biol. 2023 Dec;24(4):296-301. doi: 10.1089/ham.2023.0051

25. Rana V, Dangi M, et al. Hyperhomocysteinemia, High Altitude, and Varied Retinal Manifestations: Unravelling the Enigma. High Alt Med Biol. 2023 Sep;24(3):234-237. doi: 10.1089/ham.2023.0028

26. Ferguson SK, Redinius K, et al. Effects of living at moderate altitude on pulmonary vascular function and exercise capacity in mice with sickle cell anaemia. J Physiol. 2019 Feb;597(4):1073-1085. doi: 10.1113/JP275810

27. Boulares A, Bragazzi NL, et al. Addressing Anemia in High-Altitude Populations: Global Impact, Prevalence, Challenges, and Potential Solutions. Am J Hematol. 2025 Sep;100(9):1590-1602. doi: 10.1002/ajh.27761

28. Zhou X, Bao Q, et al. Life destiny of erythrocyte in high altitude erythrocytosis: mechanisms underlying the progression from physiological (moderate) to pathological (excessive) high-altitude erythrocytosis. Front Genet. 2025 Apr 2;16:1528935. doi: 10.3389/fgene.2025.1528935

29. Srinath R, Ahmad F, et al. New-onset seizure at high altitude among healthy males. Seizure. 2022 Apr;97:82-87. doi: 10.1016/j.seizure.2022.03.006

30. Long C, Bao H. Study of high-altitude cerebral edema using multimodal imaging. Front Neurol. 2023 Jan 26;13:1041280. doi: 10.3389/fneur.2022.1041280


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For citations:


Saktapov A., Vinnikov D., Ualiyeva A., Romanova Zh., Aitambayeva N., Nazarova L., Akhanov G., Mukanova O. NORMATIVE FRAMEWORKS AND INTERNATIONAL EVIDENCE ON OCCUPATIONAL WORK UNDER HYPOBARIC HYPOXIA IN HIGH-ALTITUDE. Actual Problems of Theoretical and Clinical Medicine. 2026;(3). https://doi.org/10.64854/2790-1289-2026-53-3-11

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