PRION DISEASES. PATHOGENS OF PRION DISEASES
https://doi.org/10.24412/2790-1289-2023-1-79-82
Abstract
Prion diseases are diseases associated with pathological proteins and based on a protein with an abnormal tertiary structure. Prions are a special class of infectious pathogens that do not have nucleic acids in their composition. They have been found in a wide range of mammalian species, including humans. Human prion diseases can occur sporadically, be hereditary or acquired. Sporadic human prion diseases include Creutzfeldt-Jakob disease (CJD), fatal insomnia, and prionopathy sensitive to various proteases. Acquired human prion diseases account for only 5% of human prion disease cases. These include chicken, iatrogenic CJD, and a new variety of CJD that has been transmitted to humans from affected cattle by eating meat, especially the brain. This review provides information about the history of discovery, the structural structure and mechanism of reproduction of the prion, types of prion diseases.
About the Authors
G. Seribekkyzy
NEI «Kazakh-Russian Medical University»
Kazakhstan
Kazakhstan
Seribekkyzy Gulzinat
Almaty
V. Galimullin
NEI «Kazakh-Russian Medical University»
Kazakhstan
Kazakhstan
Almaty
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Review
For citations:
Seribekkyzy G., Galimullin V. PRION DISEASES. PATHOGENS OF PRION DISEASES. Actual Problems of Theoretical and Clinical Medicine. 2023;(1):79-82. (In Russ.) https://doi.org/10.24412/2790-1289-2023-1-79-82
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