Objective: To compare the incidence of cardiovascular complications (CVC) in patients with persistent atrial fibrillation (AF) after dissolution of a thrombus in the left atrial appendage (LAA), as well as in patients with persistent AF without prior LAA thrombosis.
Conclusion: In patients with persistent AF, the risk of developing CVC after dissolution of a thrombus in LAA remains significantly higher than in patients with AF in whom no thrombus was detected.

This article S.Krasnova. describes a method for the diagnosis of neuropathy of the lower extremities in patients, particularly diabetes. Determined by the  temperature, tactile, pain and vibration Chuv-sitivity. Timely diagnosis of neuropathy can prevent gangrene and disability in patients

Since 2021, KazRosmeduniversity (P22) with 22 partners from 6 countries has launched a 3-year LMQS project to improve the quality of healthcare services under the Erasmus+ program. Erasmus+ is a program of the European Union aimed at promoting the modernization and sustainable development of the education system, vocational training, youth policy and sports. As a result of 9 months of work, a survey of employees of healthcare organizations was conducted to develop bachelor's and master's degree educational programs aimed at increasing the  potential of healthcare workers and ensuring the quality of medical services.

The article shows the development of a mobile application for adherence to therapy in the elderly with arterial hypertension. As a result of the work, the mobile application became available to the elderly

Based on the surgical treatment of 452 children with traumatic and orthopedic pathology and the subsequent properly organized care of the child by competent nurse with a higher education, allows to some extent to replace the concept of «care» with «treatment». Bachelor of Nursing, is the highest level performing an organizational function, observing the developed requirements which allow improving the result of surgical treatment, preventing postoperative complications.

This article presents data on the survey of students and their attitudes to the learning process with the use of innovative technologies. The questionnaire used questions that allowed us to assess the students ' interests in the educational process, in the development of practical skills. According to the results of the survey, answers were received to those questions that, in the opinion of students, can improve their professional skills. The students ' communication skills, in particular their ability to communicate with the teacher, are taken into account. The survey showed that students are ready to use innovative technologies in the educational process that will positively affect their quality of training.

Background and Objectives: Of the colorectal malignant tumors, 30 percent will arise in the rectum. The incidence of rectal cancer is increasing with the change of diet habit and genetic factors. The etiology of colon and rectal cancer is a bit different. The risks of distal colon and rectal cancer are more likely to be related to environmental factors, such as polluted surface water sources, alcohol consumption, and habitual smoking. The lack of great change in the incidence of rectal cancer might be due to weaker associations with such lifestyle factors. The study was to analyze the incidence of rectal cancer in the Central Asian republics – Kazakhstan and Kyrgyzstan.
Methods: Dates of rectal cancer patients during 2000-2010 were collected from population-based cancer registry in Kazakhstan and hospital-based registry in Kyrgyzstan. Incidence and mortality of rectal cancer were calculated and analyzed.
Results: The crude incidence of rectal cancer in Kazakhstan and Kyrgyzstan from 2000 to 2009 were 6.8 per 100 000 (7.4 per 100 000 in males, 6.2 per 100 000 in females) and 3.3 per 100 000 (3.2 per 100 000 in males and 3.4 per 100 000 in females), respectively. The incidence of rectal cancer ranked seventh (Kazakhstan) and eight (Kyrgyzstan) respectively among all cancers.The incidence of rectal cancer was increased with age at the both countries. High incidence rate of rectal cancer was registered at the Russian ethnic group, compare with native Kazakhs and Kyrgyzs. 
Conclusions: The incidence of rectal cancer is high in Kazakhstan compared to Kyrgyzstan. There are geographical and ethnic variabilities in rectal cancer incidence. High incidence rate of rectal cancer was registered in the North region of Kazakhstan, where predominance Russian population. Studies on the prevention and treatment of rectal cancer should be enhanced

The role of screening colonoscopy is the diagnosis of malignant colon neoplasms, the evaluation of other positive screening tests, the detection and removal of precancerous lesions.
Materials and methods: endoscopists were questioned, descriptive statistics methods were used.
Results and discussion: Data on the levels of endoscopists competence are presented according to the European guidelines for quality assurance in colorectal cancer screening and diagnosis (Segnan N., Patnick J., von Karsa L.).
Conclusion: Among 68 doctors (63.0 ± 4.65% of respondents) who perform screening colonoscopy, only a third of them (25 doctors) comply with the European standard of a doctor who can participate in CRC screening

This work reflects proton pump inhibitors, which today are among the most commonly prescribed drugs in gastroenterology around the world. Impact of PPIs on the severity of the clinical course of COVID-19 infection in patients.
Objective: To determine the effect of PPIs on the severity of the clinical course of COVID-19 infection in patients.
The effect of PPIs on susceptibility to SARS-COV-2. Proton pump inhibitors double the risk of contracting coronavirus infection and are
a contributor to COVID-19 infection.
Analysis of the data obtained showed that PPIs use is associated with an increased risk of a positive test for coronavirus, as already noted. Compared to respondents who do not use these drugs, those who used PPIs once or twice a day

COVID-19 poses a serious public health problem, given its enormous scale and prevalence worldwide. Direct and indirect evidence suggests that COVID-19 may worsen female fertility, which has attracted much more attention. This systematic review is aimed at analyzing the existing literature, which reports on the possible impact of coronavirus infection on the female reproductive system.

The article showsthe data of the world literature on the safety of medical personnel during surgery in patients with suspected or confirmed COVID-19 infection.

In the developed countries of the world, there are various models of organizing an emergency medical service. Ambulance abroad
consists of two models:
1. The Anglo-American model (including Japan).
2. The European model (including Israel).
The Anglo-American model (including Japan) is represented by teams of paramedics whose duties include providing emergency care and transporting patients to the emergency department of the hospital [1].
The European model (including Israel) includes both paramedics and medical teams [2, 3].
The conceptual basis of the Franco-German system is the principle of «stop and treat», aimed at ensuring that the patient is provided with the maximum possible list of services at the place of call [4,5]. The implementation of such a complex complex of diagnostic and therapeutic services at the pre-hospital stage requires the work of an experienced doctor as part of the SMP team, including for land, air and water transportation. This model works in such European countries as Germany, France, Greece, Malta and Austria [6,7].
The organization of emergency care in emergency situations in some countries has its own specifics. Let's focus on the most significant ones for large countries

Medical personal of dental clinics are most at risk of infection or transmission of COVID-19. During the pandemic, the virus has become a definite problem for dentists. It is important to define specific tasks and principles of providing basics of dental care in condition of COVID-19 pandemic.
It is necessary to take certain antiepidemic measures in the dental clinics to protect patients and medical staff from nosocomial infection.

The main goal of training future doctors is to prepare for practical activities. During lectures, practical classes, students constantly reinforce theoretical knowledge and practical skills according to the developed competencies. Improving cognitive and operational skills is inextricably linked to educational practice.

As a result of clinic investigations, it was shown that the suggested method insulation of metallic prosthetic appliance surface allows to diagnose intolerance to metallic constructions in the mouth cavity reliably to a sufficient extent, to differentiate complaints and symptoms of the disease of patients without preliminary, often groundless, removal of metallic prosthetic appliances out of the mouth cavity.

The high incidence of chronic stress fatigue syndrome and many somatic diseases that develop depending on the specifics and professional experience of dentist’s forces employers to actively implement sanitary and preventive measures in this area and create a flexible work schedule that psychologically restores working capacity. doctors are of great practical importance

NEI «Kazakh-Russian Medical University»; № 1 City Clinical Hospital, KazakhstanDespite the ongoing Sars-COV-2 pandemic, other infectious and non-infectious diseases persist in humans. Taking into account the situation in the world and in Kazakhstan, the alertness of doctors in relation to HIV infection should remain at the same level. When making not only the diagnosis of COVID-19, but also other diseases, it is necessary to rely on the worked-out criteria, since the examination and treatment tactics are based on the clinical diagnosis

Isoniazid-resistant tuberculosis (HR-TB) is characterized by resistance to isoniazid and sensitivity to rifampicin. This form can be viewed as a potential precursor to multidrug-resistant tuberculosis (MDR-TB). According to the WHO, the prevalence of HRTB is 5.0–11.0% on average. Therefore, it is of course important to control the spread of primary isoniazid resistance and prevent the amplification of resistance. WHO currently recommends treatment with rifampicin (R), ethambutol (E), pyrazinamide (Z) and levofloxacin (Lfx) for 6 months for patients with confirmed HR-TB. Since the end of 2020, this regime has begun to be implemented in the Republic of Kazakhstan. In clinical phthisiology in the country, there is not yet sufficient experience in the treatment of HR-TB. We observed the successful treatment of a patient with isoniazid-resistant TB using the 6REZLfx regimen, and the authors felt it necessary to share their experience with a wide range of TB - doctors

A new infection with SARS-COV-2 caused the development of multisystem inflammatory syndrome not only children, but also adults. General practitioners involved in the diagnosis and treatment of patients with COVID-19 should consider the possibility of developing this syndrome in adult patients, using the criteria for DFS.