The purpose of our study was to improve the results of treatment of postosteomyelitis pseudarthrosis
and long tubular bones defects using the PCI method.
Materials and methods. The study was conducted on the basis of the Aksai Republican Children's
Clinical Hospital for the period from 2000 to 2015 and the Center for Children's Emergency Medical Care
in Almaty for the period 2015 to 2022. The results of treatment of 53 children with false joints and defects
of long tubular bones that formed despite the treatment of the osteomyelitic process were studied. Based on
this material, the authors came to some conclusions.
Results. The evaluation of the results of treatment of patients was carried out according to the scale developed by us "A system for assessing the functional state of limbs with their injuries in children and adolescents". The obtained treatment results indicate the advantages of the ongoing surgical treatment
system, as well as the subsequent rehabilitation of children.
Conclusions. The determination of tactics for the treatment of post-osteomyelitic defects should
be carried out only after a complete diagnostic procedure aimed at determining the condition of bone
fragments. During treatment, it is necessary to observe the stages of restoration of damaged structures.

A clinical case of a patient with systemic scleroderma who underwent COVID-19. In systemic scleroderma, pulmonary involvement is the most common cause of death in patients is presented. Residual
lung abnormalities after the patient's discharge from the hospital mainly include frosted-glass opacities, subpleural meshes, cystic changes, and parenchymatous traction.
These features are consistent with the imaging definition of interstitial lung abnormalities. In systemic scleroderma with pulmonary involvement, computed tomography is the main tool for screening and diagnosis, and its findings influence the choice of therapy and the dynamics of follow-up.
 CT scans can provide high-resolution volumetric images of the lungs. Such scans can facilitate visualization, characterization and quantification of the extent of diffuse lung diseases such as usual interstitial pneumonitis or idiopathic pulmonary fibrosis.

Purpose. This article discusses the importance of early diagnosis of cardiotoxicity resulting from
chemotherapy treatment of cancer.
Мaterials and methods. Cardiotoxicity, a side effect of chemotherapy, can manifest at various stages
of treatment and significantly reduce patients' quality of life, increasing the risk of developing cardiovascular diseases and mortality. The work emphasizes that speckle-tracking echocardiography is an innovative
method for assessing myocardial mechanics, allowing for the detection of subclinical changes in cardiac
function at early stages. The authors examine the principles of speckle-tracking echocardiography, its advantages over traditional diagnostic methods, and the importance of integrating this method into clinical
practice to optimize treatment strategies for cancer patients.
Conclusions. The article calls for further study of speckle-tracking echocardiography and highlights
its potential role in improving prognosis and quality of life for patients undergoing chemotherapy.

The formation of a healthy lifestyle and the care of schoolchildren's health remain important and relevant tasks. Protecting the health of the younger generation is a key strategic priority for the state, as the foundation of the adult population's health is laid during childhood.
This article examines the role of a nurse in the development of school medicine. Based on a reviewof literature published in Kazakhstan, Russia, China, Lithuania and the USA, the authors note the important role of the nurse's work in creating a healthy environment in schools and the prospects for the development of this sector of medicine.
The literature review analyzes international articles and studies that emphasize the role of nurses as key participants in school medicine and explores the differences and similarities in their functional responsibilities. It also provides an in-depth analysis of the competencies required for nurses working in school medical departments.

Purpose. Chronic heart failure (CHF) is one of the most common syndromes of the
cardiovascular system (CVS) that affects the function and anatomy of the heart. Currently, the issue of the high prevalence of chronic heart failure with preserved ejection fraction (HFpEF) plays a significant role in patient mortality in healthcare. The high risk of complications and disruption of vital functions
inevitably reduces the quality of life for patients. Due to the problem of the high prevalence of chronic heart failure, we analyzed the literature on this topic.
Methods. The article presents data on the pathogenetic aspects of HFpEF based on a literature review.
Results. The role of factors such as diastolic dysfunction, myocardial fibrosis, oxidative stress, inflammation, endothelial dysfunction, etc., has been proven.
Conclusions. Thus, the pathogenesis of HFpEF is multifaceted and includes many components.
The hearts of patients with HFpEF undergo hypertrophic remodeling, and most HFpEF patients exhibit signs of diastolic dysfunction. Studying the pathogenetic mechanisms of HFpEF development can help in the further search for new therapeutic strategies.

This review is dedicated to flavonoids, which are phenolic compounds synthesized in plants from phenylalanine. The unique structure of flavonoids – comprising benzene rings and OH-radicals – accounts for their high antioxidant activity. Dihydroquercetin, due to its strong antioxidant properties, possesses anti-inflammatory, analgesic, and immunomodulatory effects. Its inhibitory action on tumor tissue growth, as well as its ability to destroy cells of several emerging malignant neoplasms, has been confirmed through experiments on cell cultures, suggesting the potential effectiveness of dihydroquercetin as an antitumor agent.
The regulatory effect of this substance on various immune system reactions and the course of inflammatory processes characterizes it as an anti-allergic and anti-inflammatory agent, capable of reducing the damaging effects of various adverse environmental factors. While it does not act directly on the pathogen, by enhancing the resistance of biological membranes and barriers, it helps the body to manage the problem on its own.

This article focuses on the study of the role of a nurse in the process of medical rehabilitation, with an emphasis on a multidisciplinary approach and a variety of tasks that a nurse performs at various stages of rehabilitation. The key points concerning patient care at all three stages of the rehabilitation process are considered, starting from the initial assessment of the patient's condition, care planning and ending with the evaluation of the results of rehabilitation. Special attention is paid to the functions of a nurse in the prevention and reduction of problems that arise in patients during rehabilitation, including the management of personal care, injury prevention and the provision of emotional support.